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KMID : 0043319960190020153
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Archives of Pharmacal Research
1996 Volume.19 No. 2 p.153 ~ p.159
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A New Streptothricin Family Antibiotic Producing Streptomyces Spp. Snus 8810-111 ; Characterization of The Producing Organisms, Fermentation, Isolation, and Structure Elucidation of Antibioitics
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Goo Yang-Mo
Kim Ok-Yun
Joe Young-Ae
Lee Young-Bok
Ju Jeong-Ho
Kim Beom-Tae
Lee Youn-Young
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Abstract
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A new streptothricin family antibiotic producing Streptomyces spp. SNUS 8810-111 was isolated from a soil sample. Study of its morphological and physiological characters indicated that the antibiotic producing organism was a Streptomyces spp. Taxonomical studies suggested that the organism might belong to the genus streptomyces gougeroti. The organism produced antibiotics most in calcium carbonate-tryptic soy broth. The active principles were recovered from the broth with a cation exchange resin and eluted from the resin with HCI. Cellulose column chromatography gave two active principles. Homo-COSY study on the first compound revealed four structural components. Total hydrolysis of the antibiotic with HCI allowed isolation of . From these data the antibiotic was found to be streptothricin D. The other compound showed one additional signal in the .NMR and the NMR spectra. The signal was from a methyl group attached to a nitrogen atom. Comparison of the NMR signals with those of streptothricin D suggested that the compound was N-methyl-streptothricin D which was a new compound in the family of streptothricin antibiotics.
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KEYWORD
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Streptomyces, Streptothricin D, N-methylstreptothricin D, Taxonomy, Strep-tomyces gougeroti, Fermentation, antibiotics
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